Description

Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-Eddnp Trifluoroacetate Salt Abz-Val-Asn-Leu-Asp-Ala-Glu-Eddnp Trifluoroacetate Salt is a specialized, high-purity fluorogenic peptide substrate designed for biochemical research. This compound is critical for the study of proteolytic enzymes, particularly those involved in the processing of the amyloid precursor protein (APP), which is central to Alzheimer's disease research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on neuroscience, enzymology, and drug discovery for neurodegenerative conditions.

Application

• Enzyme Activity Assays: As a specific fluorogenic substrate for monitoring the activity of secretase enzymes, including β-secretase (BACE1).
• Alzheimer's Disease Research: Investigating the amyloidogenic pathway and the proteolytic cleavage mechanisms of APP.
• High-Throughput Screening (HTS): Enabling the discovery and evaluation of potential therapeutic inhibitors for secretases in drug development pipelines.
• Biochemical Mechanism Studies: Used in kinetic studies to determine enzyme specificity, inhibition constants (Ki), and catalytic efficiency.
• Diagnostic Development: Serving as a key reagent in the development of in vitro diagnostic assays for enzyme dysfunction.
• Academic & Institutional Research: A fundamental tool for university and government laboratories studying protein processing and neurodegeneration.

Basic Information

Product Name	Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-Eddnp Trifluoroacetate Salt Abz-Val-Asn-Leu-Asp-Ala-Glu-Eddnp Trifluoroacetate Salt
CAS No.	1007306-20-8
Molecular Formula	C₆₀H₇₈N₁₂O₂₀ • C₂HF₃O₂ (Contact for exact stoichiometry)
Molecular Weight	~1350.3 g/mol (Free base). Contact for details on salt form.
Synonyms	APP Fluorogenic Substrate (Swedish Mutation); Abz-VNLD-AE-Eddnp; BACE1 Substrate (Fluorogenic); Amyloid Precursor Protein (669-674) Fluorogenic Peptide; (Abz)SEVNLDAEFK(Eddnp) analog; β-Secretase Substrate; APP770 (669-674) fluorogenic peptide; Abz-Val-Asn-Leu-Asp-Ala-Glu-Eddnp TFA Salt
EINECS	Contact for details

Quality Control

This high-value biochemical is manufactured under stringent conditions to ensure batch-to-batch consistency and optimal performance in sensitive assays. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and performance data. Our quality system adheres to principles of GMP for APIs where applicable, ensuring traceability and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 5.0 %
Trifluoroacetate Content (HPLC/NMR)	≤ 15%
Peptide Content	≥ 70% (by weight)
Functional Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.