Description

10-Hydroxy Warfarin β-D-Glucuronide is a key glucuronide metabolite of the anticoagulant drug warfarin. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a critical reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors requiring precise analytical measurements.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of warfarin metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and half-life of warfarin in preclinical and clinical research.
• Bioanalytical Method Development: Used to validate High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS/MS) assays for therapeutic drug monitoring (TDM).
• Toxicology and Safety Assessment: Employed in studies to understand the relationship between metabolite levels and drug efficacy or toxicity profiles.
• Academic and Institutional Research: A vital tool for universities and research institutes studying anticoagulant therapies, cytochrome P450 enzyme activity, and glucuronidation processes.
• Quality Control in Manufacturing: Supports impurity profiling and stability testing of warfarin active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	10-Hydroxy Warfarin β-D-Glucuronide
CAS No.	1007224-61-4
Molecular Formula	C26H32O11
Molecular Weight	520.53 g/mol
Synonyms	10-Hydroxywarfarin β-D-Glucuronide; 10-Hydroxywarfarin Glucuronide; Warfarin 10-O-β-D-Glucuronide; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 10-(β-D-Glucopyranosiduronic Acid); 10-Hydroxywarfarin β-Glucuronide; 10-OH-Warfarin Glucuronide; 10-Hydroxy Coumarin Glucuronide Derivative
EINECS	Contact for details

Quality Control

Our 10-Hydroxy Warfarin β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.