Description

8-Hydroxy Warfarin β-D-Glucuronide is a key glucuronide metabolite of the anticoagulant drug warfarin. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the biochemical pathways of anticoagulants. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory safety testing.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of warfarin metabolites in biological matrices (e.g., plasma, urine) using LC-MS/MS and HPLC methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic fate, clearance pathways, and exposure levels of warfarin in preclinical and clinical studies.
• Metabolite Synthesis and Characterization: Acts as a synthetic intermediate or a standard for the preparation and structural confirmation of other related warfarin metabolites.
• Enzyme Activity Assays: Employed in studies to assess the activity of UDP-glucuronosyltransferase (UGT) enzymes responsible for the glucuronidation phase II metabolic pathway.
• Toxicological and Safety Assessment: Utilized in safety testing to understand the profile and potential activity of warfarin metabolites.
• Academic and Institutional Research: Supports fundamental research in medicinal chemistry, pharmacology, and biochemistry related to anticoagulant therapies.

Basic Information

Product Name	8-Hydroxy Warfarin β-D-Glucuronide
CAS No.	1007224-60-3
Molecular Formula	C26H32O12
Molecular Weight	536.53 g/mol
Synonyms	8-Hydroxywarfarin β-D-Glucuronide; Warfarin 8-O-β-D-Glucuronide; 8-Hydroxywarfarin Glucuronide; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 8-β-D-Glucopyranosiduronic Acid; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-((4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-oxo-2H-chromen-8-yl)oxy)tetrahydro-2H-pyran-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 8-Hydroxy Warfarin β-D-Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, LC-MS confirmation, and NMR structural verification, to ensure identity, potency, and purity meet the stringent requirements for reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.