Description

6-Hydroxy Warfarin β-D-Glucuronide is a high-purity, conjugated metabolite of the anticoagulant drug warfarin. This compound is of critical importance for pharmaceutical research and development, serving as a key reference standard and analytical tool. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and regulatory compliance testing.

Application

• Pharmacokinetic and Metabolism Studies: Used as a certified reference standard to quantify and characterize the metabolic profile of warfarin in biological matrices.
• Bioanalytical Method Development and Validation: Essential for developing and validating sensitive and specific LC-MS/MS or HPLC methods for drug metabolite analysis.
• DMPK (Drug Metabolism and Pharmacokinetics) Research: Aids in understanding the Phase II glucuronidation pathway of warfarin, a critical factor in its efficacy and safety profile.
• Clinical Research and Toxicology: Employed in studies investigating drug-drug interactions, genetic polymorphisms in metabolizing enzymes, and personalized medicine approaches for anticoagulant therapy.
• Quality Control in Pharmaceutical Manufacturing: Serves as a system suitability standard and for impurity profiling in the production of warfarin and related compounds.
• Regulatory Submissions: Provides essential data to support Investigational New Drug (IND) and New Drug Application (NDA) filings with agencies like the FDA and EMA.

Basic Information

Product Name	6-Hydroxy Warfarin β-D-Glucuronide
CAS No.	1007224-59-0
Molecular Formula	C26H32O11
Molecular Weight	520.53 g/mol
Synonyms	6-Hydroxywarfarin β-D-Glucuronide; Warfarin 6-O-β-D-Glucuronide; 6-OH Warfarin Glucuronide; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 6-(β-D-Glucopyranosiduronic Acid); 6-Hydroxywarfarin Glucuronide; Warfarin Metabolite Glucuronide; (6-Hydroxy-4-oxo-3-phenyl-2H-chromen-2-yl) 3,4,5-trihydroxy-6-[(1S)-1-hydroxy-2-oxo-2-phenylethyl]oxyoxane-2-carboxylate
EINECS	Contact for details

Quality Control

Our 6-Hydroxy Warfarin β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and regulatory applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated at the recommended temperature. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.