Description

3-(Benzyloxy)-4-(Trifluoromethyl)Phenylboronic Acid is a high-value boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its molecular structure, featuring both a benzyl-protected phenol and a trifluoromethyl group, makes it an essential reagent for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by manufacturers of advanced materials and liquid crystals.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the phenylboronic acid moiety enables efficient carbon-carbon bond formation.
• Material Science: Serves as a monomer or precursor in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure can influence charge transport properties.
• Liquid Crystal Manufacturing: Employed in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for drug discovery.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl structures, a fundamental transformation in medicinal chemistry.

Basic Information

Product Name	3-(Benzyloxy)-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1007170-59-3
Molecular Formula	C14H12BF3O3
Molecular Weight	296.05 g/mol
Synonyms	[4-(Benzyloxy)-3-(trifluoromethyl)phenyl]boronic acid; 3-Benzyloxy-4-trifluoromethylbenzeneboronic acid; (3-(Benzyloxy)-4-(trifluoromethyl)phenyl)boronic acid; B-[4-(Benzyloxy)-3-(trifluoromethyl)phenyl]boronic acid; 4-Benzyloxy-3-trifluoromethylphenylboronic acid; 3-(Benzyloxy)-4-(trifluoromethyl)benzeneboronic acid
EINECS	Contact for details

Quality Control

Our 3-(Benzyloxy)-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.