Description

3-Iodo-4-Methylamino-Benzonitrile is a high-purity, functionalized benzonitrile derivative featuring both iodine and methylamino substituents. This compound serves as a versatile and critical synthetic intermediate, enabling the construction of complex molecular architectures in advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials chemists for applications in medicinal chemistry, ligand synthesis, and the development of organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the production of specialty polymers, liquid crystals, and organic semiconductors.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form new carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized for synthesizing novel chelating ligands for metal complexes used in catalysis and sensing applications.
• Chemical Biology Probes: Acts as a starting material for creating molecular probes to study biological pathways and protein functions.

Basic Information

Product Name	3-Iodo-4-Methylamino-Benzonitrile
CAS No.	1006727-97-4
Molecular Formula	C8H7IN2
Molecular Weight	258.06 g/mol
Synonyms	4-(Methylamino)-3-iodobenzonitrile; 3-Iodo-4-(methylamino)benzonitrile; 4-Methylamino-3-iodobenzonitrile; Benzonitrile, 3-iodo-4-(methylamino)-; 1006727-97-4; 3-I-4-MABN
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-4-Methylamino-Benzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.