Description

Alfuzosin-D3 is a deuterium-labeled analog of the selective α-1 adrenergic receptor antagonist Alfuzosin, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity reference material is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolic research, particularly in drug development and clinical testing. It is an essential tool for analytical laboratories and pharmaceutical R&D teams requiring precise mass spectrometry-based quantification.

Application

• Primary use as an Internal Standard (IS) in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods.
• Quantitative bioanalysis of Alfuzosin in pharmacokinetic studies to determine drug concentration in biological matrices (plasma, serum, urine).
• Metabolite profiling and drug metabolism and pharmacokinetics (DMPK) research.
• Method development and validation in contract research organizations (CROs) and pharmaceutical quality control labs.
• Supporting clinical trial research for generics and new formulations containing Alfuzosin.
• Use in forensic and anti-doping analysis for precise quantification.

Basic Information

Product Name	Alfuzosin-D3
CAS No.	1006724-55-5
Molecular Formula	C₁₉H₂₄D₃N₅O₄
Molecular Weight	392.47 g/mol
Synonyms	Alfuzosin (phenyl-d3); Alfuzosin-d3; N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide-d3; (RS)-N-[3-[(4-Amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]tetrahydrofuran-2-carboxamide-d3; Alfuzosin Internal Standard; Deuterated Alfuzosin
EINECS	Contact for details

Quality Control

Our Alfuzosin-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant guidelines for reference standards to support GMP and GLP compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.