Description

Prazosin-D8 is a deuterated analog of the α-1 adrenergic receptor antagonist Prazosin, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical reagent for pharmaceutical research, bioanalytical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and clinical diagnostics.

Application

• Internal Standard for LC-MS/MS quantification of Prazosin and its metabolites in biological matrices (plasma, serum, urine).
• Use in Drug Metabolism and Pharmacokinetics (DMPK) studies to track drug absorption, distribution, metabolism, and excretion (ADME).
• Critical component in bioanalytical method development and validation for regulatory submissions (FDA, EMA).
• High-precision calibration in forensic toxicology and clinical diagnostic assays.
• Research tool in cardiovascular and urological studies investigating α-blocker mechanisms.
• Quality control standard for pharmaceutical manufacturing of Prazosin-based APIs and finished dosage forms.

Basic Information

Product Name	Prazosin-D8
CAS No.	1006717-55-0
Molecular Formula	C19H13D8ClN5O4
Molecular Weight	391.88 g/mol (deuterated form)
Synonyms	Prazosin-d8; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,2,3,3,5,5,6,6-octadeuterio-2-furanyl)carbonyl]piperazine; Deuterated Prazosin; Prazosin Internal Standard; [2H8]-Prazosin; Furazosin-d8; CP-12299-1-d8; Hypovase-d8; Minipress-d8
EINECS	Contact for details

Quality Control

Every batch of Prazosin-D8 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (typically ≥98 atom % D), chemical purity (by HPLC), and confirmation of structure. Our quality protocols are designed to meet the stringent requirements of GMP/GLP-compliant laboratories, ensuring traceability and consistency for critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive). Store under an inert atmosphere if the container is opened repeatedly.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.