Description

1-(2,2,2-Trifluoroethyl)-1H-Pyrazole-4-Sulfonyl Chloride is a high-value, reactive sulfonyl chloride derivative used as a key synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in its role as a versatile building block for constructing complex molecules with tailored properties, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing novel active ingredients, where its trifluoroethyl-pyrazole scaffold and reactive sulfonyl chloride group enable the introduction of sulfonamide functionalities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic, oncological, and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the sulfonamide moiety can enhance biological activity and selectivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling, modifying, or inhibiting biological targets in probe and tool compound development.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)-1H-Pyrazole-4-Sulfonyl Chloride
CAS No.	1006487-19-9
Molecular Formula	C5H4ClF3N2O2S
Molecular Weight	248.61 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-1H-pyrazole-4-sulfonyl chloride; 1H-Pyrazole-4-sulfonyl chloride, 1-(2,2,2-trifluoroethyl)-; 1-(Trifluoroethyl)pyrazole-4-sulfonyl chloride; 4-(Chlorosulfonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole; 1-(2,2,2-Trifluoroethyl)pyrazole-4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroethyl)-1H-Pyrazole-4-Sulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.