Description

1-(2,2-Difluoroethyl)-1H-Pyrazole-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its pyrazole-carboxylic acid core and difluoroethyl substituent. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine chemistry. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of agrochemicals and life-saving medications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting metabolic and central nervous system disorders.
• Agrochemical Research: Serves as a key scaffold for developing new-generation herbicides and pesticides with enhanced efficacy and environmental profile.
• Chemical Biology & Proteomics: Used as a specialized reagent or linker in the design of chemical probes for target identification and validation.
• Material Science: Potential application as a monomer or additive in the development of specialty polymers with unique fluorinated properties.
• Academic & Industrial R&D: Employed in exploratory chemistry for method development and the creation of novel chemical libraries.

Basic Information

Item	Details
Product Name	1-(2,2-Difluoroethyl)-1H-Pyrazole-3-Carboxylic Acid
CAS No.	1006486-39-0
Molecular Formula	C6H6F2N2O2
Molecular Weight	176.12 g/mol
Synonyms	1-(2,2-Difluoroethyl)-1H-pyrazole-3-carboxylic acid; 1H-Pyrazole-3-carboxylic acid, 1-(2,2-difluoroethyl)-; 3-Pyrazolecarboxylic acid, 1-(2,2-difluoroethyl)-; 1-(Difluoroethyl)pyrazole-3-carboxylic acid; DFEPCA; 1006486-39-0
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoroethyl)-1H-Pyrazole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.