Description

1-{[3-(Trifluoromethyl)Phenoxy]Methyl}-1H-Pyrazol-4-Amine is a high-value, functionalized pyrazole derivative featuring a trifluoromethylphenoxy moiety, making it a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules with tailored properties, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine and heterocyclic motifs for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in areas like kinase inhibitors, anti-inflammatory agents, and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorine-containing aromatic units.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reaction pathways and creating libraries of compounds for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke chemicals for client projects.

Basic Information

Product Name	1-{[3-(Trifluoromethyl)Phenoxy]Methyl}-1H-Pyrazol-4-Amine
CAS No.	1006333-99-8
Molecular Formula	C11H10F3N3O
Molecular Weight	257.21 g/mol
Synonyms	1-[(3-Trifluoromethylphenoxy)methyl]-1H-pyrazol-4-amine; 1-((3-(Trifluoromethyl)phenoxy)methyl)-1H-pyrazol-4-amine; 4-Amino-1-[(3-trifluoromethylphenoxy)methyl]pyrazole; 1H-Pyrazol-4-amine, 1-[[3-(trifluoromethyl)phenoxy]methyl]-; 1006333-99-8; 1-{[3-(Trifluoromethyl)Phenoxy]Methyl}-1H-Pyrazol-4-Amine
EINECS	Contact for details

Quality Control

Our 1-{[3-(Trifluoromethyl)Phenoxy]Methyl}-1H-Pyrazol-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.