Description

1-Chloro-3-Fluoro-5-(Trifluoromethyl)Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. This compound matters for its unique trifluoromethyl and halogen substitution pattern, which imparts significant lipophilicity, metabolic stability, and electronic properties to target molecules. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS, oncology, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorine-containing liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Polymer & Resin Modifier: Incorporated into specialty polymers and resins to enhance chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new fluorinated compounds and reaction pathways.

Basic Information

Product Name	1-Chloro-3-Fluoro-5-(Trifluoromethyl)Benzene
CAS No.	1005764-23-7
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	3-Chloro-5-Fluorobenzotrifluoride; 5-Chloro-1-Fluoro-3-(Trifluoromethyl)Benzene; 1-Chloro-3-Fluoro-5-(Trifluoromethyl) Benzene; 3-Chloro-α,α,α-Trifluoro-5-Fluorotoluene; 3-Chloro-5-Fluoro Benzotrifluoride; 5-Chloro-1-Fluoro-3-Trifluoromethylbenzene; 3-Chloro-5-Fluoro(trifluoromethyl)benzene; Benzene, 1-chloro-3-fluoro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-Fluoro-5-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.