Description

3-Methoxy-4-(Trifluoromethyl)Phenylboronic Acid is a high-value organoboron building block characterized by its unique methoxy and trifluoromethyl substituents. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides, leveraging the boronic acid functionality for efficient carbon-carbon bond formation in active ingredient development.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, where its aromatic core and substituents contribute to desired electronic properties and molecular alignment.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and functionalized materials requiring specific aromatic units introduced via cross-coupling.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic routes and creating compound libraries for screening.

Basic Information

Product Name	3-Methoxy-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1004775-33-0
Molecular Formula	C8H8BF3O3
Molecular Weight	219.96 g/mol
Synonyms	[3-Methoxy-4-(trifluoromethyl)phenyl]boronic acid; (3-Methoxy-4-(trifluoromethyl)phenyl)boronic acid; 4-Trifluoromethyl-3-methoxyphenylboronic acid; 3-Methoxy-4-trifluoromethylbenzeneboronic acid; Boronic acid, B-[3-methoxy-4-(trifluoromethyl)phenyl]-; 1004775-33-0; 3-Methoxy-α,α,α-trifluoro-p-tolylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Methoxy-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling reactions. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.