Description

1-Bromo-3-Chloro-5-(Difluoromethoxy)Benzene is a high-purity, multi-functional halogenated benzene derivative designed for advanced chemical synthesis. This compound serves as a critical building block in the development of complex molecules, offering unique reactivity for introducing specific functional groups. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluoromethoxy-phenyl moiety.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen and ether groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination to construct complex biaryl systems.
• Fluorine Chemistry: The difluoromethoxy group makes it a valuable scaffold for studying the effects of fluorine substitution in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Item	Detail
Product Name	1-Bromo-3-Chloro-5-(Difluoromethoxy)Benzene
CAS No.	1004112-67-7
Molecular Formula	C7H4BrClF2O
Molecular Weight	257.46 g/mol
Synonyms	3-Bromo-5-Chloro-1-(Difluoromethoxy)Benzene; 5-Bromo-3-Chloro-1-(Difluoromethoxy)Benzene; 1-(Difluoromethoxy)-3-Bromo-5-Chlorobenzene; Benzene, 1-bromo-3-chloro-5-(difluoromethoxy)-; 3-Chloro-5-bromo(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-5-(Difluoromethoxy)Benzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.