Description

(3-Chloro-5-Fluoro-4-Hydroxyphenyl)Boronic Acid is a high-purity, multi-functional boronic acid derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for drug discovery, catalyst development, and the synthesis of functional organic molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Employed as a building block for creating advanced herbicides, fungicides, and insecticides with improved efficacy.
• Ligand and Catalyst Development: Useful in the preparation of novel boron-containing ligands for catalytic systems and metal-organic frameworks (MOFs).
• Materials Science Research: Incorporated into the synthesis of organic electronic materials, such as those used in OLEDs and sensors.
• Chemical Biology Probes: Serves as a handle for bioconjugation and the development of activity-based probes for studying biological processes.

Basic Information

Item	Detail
Product Name	(3-Chloro-5-Fluoro-4-Hydroxyphenyl)Boronic Acid
CAS No.	1003298-72-3
Molecular Formula	C6H5BClFO3
Molecular Weight	189.37 g/mol
Synonyms	3-Chloro-5-fluoro-4-hydroxybenzeneboronic acid; (3-Chloro-5-fluoro-4-hydroxyphenyl)boronic acid; 4-Borono-2-chloro-6-fluorophenol; 2-Chloro-6-fluoro-4-hydroxybenzeneboronic acid; B-(3-Chloro-5-fluoro-4-hydroxyphenyl)boronic acid; 3-Chloro-5-fluoro-4-hydroxy-phenylboronic acid; CAS 1003298-72-3
EINECS	Contact for details

Quality Control

Our (3-Chloro-5-Fluoro-4-Hydroxyphenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support development and commercial projects requiring material that meets stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.