Description

(Rp)-1-[(R)-α-(Dimethylamino)-2-(Diphenylphosphino)Benzyl]-2-Diphenylphosphinoferrocene is a highly specialized, chiral ferrocenyl phosphine ligand designed for asymmetric catalysis. This compound matters for its ability to impart exceptional enantioselectivity and catalytic activity in critical synthetic transformations, enabling the production of high-value, optically pure intermediates. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for developing novel synthetic routes and scaling up production of chiral active ingredients.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Catalyzes cross-coupling and addition reactions, such as Rhodium or Iridium-catalyzed allylic substitutions, to construct chiral carbon centers.
• Process Chemistry & Scale-up: Employed in the development and optimization of commercial-scale manufacturing processes for chiral drugs and agrochemicals.
• Academic & Industrial R&D: Serves as a critical tool for discovering new catalytic methodologies and synthesizing novel chiral compounds in research laboratories.
• Fine Chemical Synthesis: Used in the production of specialty chemicals, flavors, fragrances, and advanced materials requiring high optical purity.

Basic Information

Product Name	(Rp)-1-[(R)-α-(Dimethylamino)-2-(Diphenylphosphino)Benzyl]-2-Diphenylphosphinoferrocene
CAS No.	1003012-96-1
Molecular Formula	C43H41FeNP2
Molecular Weight	689.58 g/mol
Synonyms	(R,R)-Walphos SL-W008-1; (R,R)-Walphos; (R,R)-1-[(R)-2-(Dimethylamino)-1-(diphenylphosphino)benzyl]-2-(diphenylphosphino)ferrocene; Josiphos-type ligand derivative; Chiral ferrocenyl diphosphine ligand; SL-W008-1; (R)-1-[(S)-2-(Dimethylamino)-1-(diphenylphosphino)benzyl]-2-(diphenylphosphino)ferrocene (enantiomer)
EINECS	Contact for details

Quality Control

Our production of (Rp)-1-[(R)-α-(Dimethylamino)-2-(Diphenylphosphino)Benzyl]-2-Diphenylphosphinoferrocene adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.