Description

Rac-cis-7-Hydroxy Pramipexole CAS NO 1001648-71-0 is a key pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is primarily valued for its role in the synthesis and analytical profiling of pramipexole, a widely used dopamine agonist medication. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on neurology and drug metabolism studies. The material is critical for ensuring product quality, process validation, and regulatory compliance in advanced pharmaceutical production.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Pramipexole and its related analogs.
• Reference Standard: Used as a certified standard in analytical methods (e.g., HPLC, LC-MS) for quality control and impurity profiling of active pharmaceutical ingredients (APIs).
• Metabolite Studies: Employed in pharmacological and pharmacokinetic research to study the metabolism and biological activity of Pramipexole.
• Process Development & Validation: Essential for developing, optimizing, and validating synthetic routes in pharmaceutical R&D.
• Impurity Identification: Serves as a marker for identifying and quantifying related substances in final drug products to meet ICH guidelines.
• Research Chemical: Used in academic and industrial research to explore new therapeutic applications and structure-activity relationships (SAR).

Basic Information

Product Name	Rac-cis-7-Hydroxy Pramipexole
CAS No.	1001648-71-0
Molecular Formula	C10H17N3OS
Molecular Weight	227.33 g/mol
Synonyms	(6S)-6-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine 7-ol; 7-Hydroxy Pramipexole; Pramipexole 7-ol; Pramipexole Hydroxy Metabolite; 2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazol-7-ol; (6S)-6-(Propylamino)-4,5,6,7-tetrahydro-1,3-benzothiazole-2,7-diamine; rac-cis-7-Hydroxy Pramipexole
EINECS	Contact for details

Quality Control

Our Rac-cis-7-Hydroxy Pramipexole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (IR, NMR, MS) to ensure identity and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, supporting your regulatory submissions and supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.