Description

Boc-(S)-3-Amino-2-(4-Chlorophenyl)Propanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This chiral building block is critical for introducing the (S)-2-amino-3-(4-chlorophenyl)propanoic acid moiety into complex molecules under standard Boc-chemistry conditions. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of novel therapeutic peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a phenylalanine derivative with a para-chloro substituent.
• Medicinal Chemistry: Serves as a crucial building block for constructing combinatorial libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Bioconjugation: Employed in the synthesis of peptide conjugates for targeted drug delivery systems and diagnostic probes.
• Chemical Biology: Useful as a tool compound for studying enzyme-substrate interactions and designing enzyme inhibitors.
• Process Chemistry: Applied in the scale-up and optimization of synthetic routes for GMP manufacturing of peptide therapeutics.

Basic Information

Product Name	Boc-(S)-3-Amino-2-(4-Chlorophenyl)Propanoic Acid
CAS No.	1001180-04-6
Molecular Formula	C₁₄H₁₈ClNO₄
Molecular Weight	299.75 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-chlorophenyl)propanoic acid; Boc-DL-4-Chlorophenylalanine; N-Boc-4-Chloro-DL-phenylalanine; tert-Butyl (S)-2-amino-3-(4-chlorophenyl)propanoate; N-(tert-Butoxycarbonyl)-4-chloro-DL-phenylalanine; Boc-4-Cl-Phe-OH; (S)-3-(4-Chlorophenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid
EINECS	Contact for details

Quality Control

Our Boc-(S)-3-Amino-2-(4-Chlorophenyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and development. A Certificate of Analysis (COA) detailing identity, purity (typically >98%), and impurity profiles is provided with every shipment to guarantee reproducible results and supply chain reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.