Description

3-Bromo-4-Iodobenzonitrile is a high-purity halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its unique bifunctional halogen pattern makes it an indispensable intermediate for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides requiring specific halogenated aromatic cores.
• Material Science: Building block for organic electronic materials, including organic light-emitting diodes (OLEDs) and liquid crystals.
• Cross-Coupling Reactions: Essential substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the orthogonal reactivity of the bromo and iodo substituents.
• Chemical Research: Versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.
• Ligand Preparation: Intermediate for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Bromo-4-Iodobenzonitrile
CAS No.	1000577-94-5
Molecular Formula	C7H3BrIN
Molecular Weight	307.92 g/mol
Synonyms	4-Iodo-3-bromobenzonitrile; Benzonitrile, 3-bromo-4-iodo-; 3-Bromo-4-iodobenzonitrile; 3-Bromo-4-cyanoidobenzene; 4-Cyano-2-bromo-1-iodobenzene; 2-Bromo-4-cyanoidobenzene; 1-Bromo-2-iodo-4-cyanobenzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Iodobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.