Description

1-Bromo-3-Chloro-5-Fluoro-2-Iodobenzene is a highly functionalized, multi-halogenated benzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an exceptionally versatile intermediate for constructing complex molecular architectures where precise halogen placement is required. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce aryl groups.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging its halogen handles for further functionalization.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for imaging and diagnostic applications due to the presence of iodine, which is useful for radiolabeling.
• Organic Synthesis Scaffold: Provides a rigid, multi-halogenated core for systematic derivatization in medicinal chemistry and discovery chemistry programs.
• Catalyst & Ligand Preparation: Used to synthesize sophisticated ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	1-Bromo-3-Chloro-5-Fluoro-2-Iodobenzene
CAS No.	1000577-66-1
Molecular Formula	C6H2BrClFI
Molecular Weight	335.34 g/mol
Synonyms	2-Bromo-6-Chloro-4-Fluoro-1-Iodobenzene; 3-Chloro-5-Fluoro-2-Iodo-1-Bromobenzene; 1-Bromo-3-chloro-5-fluoro-2-iodo-Benzene; Benzene, 1-bromo-3-chloro-5-fluoro-2-iodo-; BCFI-Benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-5-Fluoro-2-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.