Description

1-Bromo-2-Chloro-4,5,6-Trifluorobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the halogen pattern contributes to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce halogenated aromatic units into polymer chains, enhancing flame retardancy and chemical resistance.
• Cross-Coupling Reactions: The bromine and chlorine atoms provide distinct sites for selective metal-catalyzed cross-coupling (e.g., Suzuki, Negishi) to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other reactions specific to perfluorinated arenes.

Basic Information

Item	Detail
Product Name	1-Bromo-2-Chloro-4,5,6-Trifluorobenzene
CAS No.	1000577-28-5
Molecular Formula	C6HBrClF3
Molecular Weight	239.42 g/mol
Synonyms	2-Bromo-1-Chloro-3,4,5-Trifluorobenzene; 1-Chloro-2-Bromo-4,5,6-Trifluorobenzene; Benzene, 1-bromo-2-chloro-4,5,6-trifluoro-; 4,5,6-Trifluoro-1-bromo-2-chlorobenzene; BCTFB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-4,5,6-Trifluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.