Description

4-Bromo-1-Chloro-2-(Difluoromethoxy)Benzene is a high-purity halogenated benzene derivative, a key advanced intermediate in modern organic synthesis. Its value lies in its unique difluoromethoxy and halogen substitution pattern, which is crucial for introducing specific physicochemical properties into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances bioavailability and stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology & Proteomics: Employed as a versatile probe or linker molecule in bioconjugation and the development of chemical tools for biological target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	4-Bromo-1-Chloro-2-(Difluoromethoxy)Benzene
CAS No.	1000575-20-1
Molecular Formula	C7H4BrClF2O
Molecular Weight	257.46 g/mol
Synonyms	2-Bromo-5-Chloro-1-(Difluoromethoxy)Benzene; 1-Bromo-4-Chloro-2-(Difluoromethoxy)Benzene; 4-Bromo-1-Chloro-2-(Difluoromethoxy)benzene; Benzene, 4-bromo-1-chloro-2-(difluoromethoxy)-; 2-(Difluoromethoxy)-4-bromo-1-chlorobenzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Chloro-2-(Difluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.