Description

2-(2-Chloropyridin-4-Yl)Acetonitrile is a versatile and high-value pyridine derivative building block essential for advanced organic synthesis. Its molecular structure, featuring both a chloropyridine ring and a reactive nitrile group, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to build pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	2-(2-Chloropyridin-4-Yl)Acetonitrile
CAS No.	1000565-45-6
Molecular Formula	C7H5ClN2
Molecular Weight	152.58 g/mol
Synonyms	4-(Cyanomethyl)-2-chloropyridine; 2-Chloro-4-(cyanomethyl)pyridine; (2-Chloro-4-pyridinyl)acetonitrile; 2-Chloropyridine-4-acetonitrile; 2-Chloro-4-pyridylacetonitrile; Acetonitrile, (2-chloro-4-pyridinyl)-; 1000565-45-6
EINECS	Contact for details

Quality Control

Our 2-(2-Chloropyridin-4-Yl)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.