Description

3-Chloro-5-Fluoro-4-Methoxyphenylacetonitrile, 97% is a high-purity, multi-functional aromatic nitrile building block essential for advanced organic synthesis. Its value lies in the strategic positioning of halogen and methoxy substituents, which enable precise structural modifications in complex molecule construction. This intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted phenylacetonitrile core.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the chloro-fluoro-methoxy pattern confers specific bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized monomers or advanced organic materials for electronic or optical applications.
• Custom Chemical Synthesis: A versatile building block for contract research organizations (CROs) and CDMOs serving diverse client projects.
• Library Compound Generation: Used in medicinal chemistry for generating focused compound libraries via further derivatization of the nitrile group.

Basic Information

Product Name	3-Chloro-5-Fluoro-4-Methoxyphenylacetonitrile, 97%
CAS No.	1000540-93-1
Molecular Formula	C9H7ClFNO
Molecular Weight	199.61 g/mol
Synonyms	(3-Chloro-5-fluoro-4-methoxyphenyl)acetonitrile; 2-(3-Chloro-5-fluoro-4-methoxyphenyl)acetonitrile; 3-Chloro-5-fluoro-4-methoxybenzyl cyanide; 1000540-93-1; 3-Chloro-5-fluoro-p-anisylacetonitrile; 4-Methoxy-3-chloro-5-fluorophenylacetonitrile; α-(3-Chloro-5-fluoro-4-methoxyphenyl)acetonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Fluoro-4-Methoxyphenylacetonitrile is produced and tested under a strict quality management system. We guarantee a minimum purity of 97% (typically by HPLC), with comprehensive identity confirmation and impurity profiling. Certificates of Analysis (COA) detailing all relevant specifications are provided with each shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.