Description

3-Chloro-4-(Trifluoromethyl)Phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemical active ingredients due to its unique trifluoromethyl and chloro substituents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to introduce the potent trifluoromethyl group into target molecules, enhancing their metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes.
• Functional Polymer Monomer: Serves as a precursor for monomers that impart special chemical resistance and surface properties to high-performance polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Details
Product Name	3-Chloro-4-(Trifluoromethyl)Phenylacetonitrile
CAS No.	1000530-58-4
Molecular Formula	C9H5ClF3N
Molecular Weight	219.59 g/mol
Synonyms	2-(3-Chloro-4-(trifluoromethyl)phenyl)acetonitrile; [3-Chloro-4-(trifluoromethyl)phenyl]acetonitrile; 3-Chloro-α-tolunitrile, 4-(trifluoromethyl)-; α-(3-Chloro-4-(trifluoromethyl)phenyl)acetonitrile; (3-Chloro-4-trifluoromethylphenyl)acetonitrile; 2-(3-Chloro-4-trifluoromethylphenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. We provide material with typical purities of ≥97% (by HPLC), tailored to meet the stringent requirements of process chemistry and scale-up. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality commitment ensures consistency and reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.