Description

Benzeneacetic Acid, 4-(Difluoromethyl)- is a specialized fluorinated aromatic acid derivative, identified by CAS No. 1000524-74-2. This compound is valued for its unique difluoromethyl substituent, which can significantly alter the physicochemical and metabolic properties of target molecules, making it a critical building block in advanced synthesis. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly where fluorine substitution is used to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the design and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance activity and environmental profile.
• Liquid Crystal & OLED Material Research: Serves as a precursor or functional component in the development of specialty electronic and display materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide bond formations to introduce the difluoromethylphenylacetic acid moiety into complex molecular architectures.
• Biochemical Probe Development: Useful in medicinal chemistry for creating labeled compounds or probes to study biological pathways and enzyme interactions.

Basic Information

Product Name	Benzeneacetic Acid, 4-(Difluoromethyl)-
CAS No.	1000524-74-2
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	4-(Difluoromethyl)phenylacetic Acid; 2-[4-(Difluoromethyl)phenyl]acetic Acid; p-(Difluoromethyl)phenylacetic Acid; α-(4-(Difluoromethyl)phenyl)acetic Acid; (4-(Difluoromethyl)phenyl)ethanoic Acid; DFMPAA; 1000524-74-2 (CAS)
EINECS	Contact for details

Quality Control

Our Benzeneacetic Acid, 4-(Difluoromethyl)- is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.