Description

2-Diphenyphosphino-2'-Hydroxyl-1,1'-Binaphthyl CAS NO 199796-91-3 is a sophisticated chiral ligand belonging to the binaphthyl phosphine class, prized for its unique structural configuration that imparts excellent stereoselectivity in catalytic reactions. This compound is essential for enabling highly efficient and selective asymmetric synthesis, a cornerstone of modern pharmaceutical and fine chemical manufacturing. It is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over molecular chirality.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, such as Suzuki-Miyaura and Heck reactions, to construct chiral centers with high enantiomeric excess.
• Catalyst Development: Serves as a critical component in the design and preparation of novel transition metal catalysts for academic and industrial research.
• Pharmaceutical Intermediate Production: Used in the synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, including chiral drugs for CNS, cardiovascular, and oncological applications.
• Agrochemical Synthesis: Facilitates the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Applied in the development of chiral polymers and advanced organic frameworks with specific optical properties.

Basic Information

Product Name	2-Diphenyphosphino-2'-Hydroxyl-1,1'-Binaphthyl
CAS No.	199796-91-3
Molecular Formula	C32H23O1P1
Molecular Weight	454.50 g/mol
Synonyms	(R)-2-Diphenylphosphino-2'-hydroxy-1,1'-binaphthyl; (R)-2-(Diphenylphosphino)-2'-hydroxy-1,1'-binaphthyl; (R)-HOBINAP; (R)-2-(Diphenylphosphino)-2'-hydroxy-1,1'-binaphthyl; (R)-2'-Hydroxy-2-diphenylphosphino-1,1'-binaphthyl; (R)-2-Diphenylphosphino-2'-hydroxy-1,1'-binaphthalene; HOBINAP Ligand; (R)-HOBINAP Ligand
EINECS	Contact for details

Quality Control

Our 2-Diphenyphosphino-2'-Hydroxyl-1,1'-Binaphthyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for catalytic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.