Description

Amino-(3,5-Difluoro-Phenyl)-Acetic Acid is a high-purity fluorinated aromatic amino acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can significantly alter the electronic properties, metabolic stability, and binding affinity of final target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring precise molecular tuning.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics where fluorine substitution is desirable.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging fluorine's ability to enhance biological activity and environmental persistence.
• Peptide Mimetics & Conjugation: Functions as a non-natural amino acid analog for constructing peptide-based drugs and diagnostic agents, improving proteolytic stability and pharmacokinetic profiles.
• Ligand & Catalyst Development: Employed in organometallic chemistry and catalysis research to create novel chiral ligands or metal-organic frameworks (MOFs) with tailored properties.
• Material Science Precursor: Serves as a starting material for synthesizing specialized polymers, liquid crystals, or organic electronic materials that incorporate fluorinated aromatic units.
• Bioconjugation & Probe Synthesis: Useful for labeling biomolecules or creating fluorescent probes and other chemical biology tools due to its reactive amino and carboxylic acid functional groups.

Basic Information

Product Name	Amino-(3,5-Difluoro-Phenyl)-Acetic Acid
CAS No.	199327-33-8
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	2-Amino-2-(3,5-difluorophenyl)acetic acid; (3,5-Difluorophenyl)glycine; DL-3,5-Difluorophenylglycine; 3,5-Difluoro-DL-phenylglycine; Amino(3,5-difluorophenyl)ethanoic acid; 2-(3,5-Difluorophenyl)aminoacetic acid; NSC 759108
EINECS	Contact for details

Quality Control

Our Amino-(3,5-Difluorophenyl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.