Description

2-Fluoro-5-(trifluoromethyl)benzylamine is a high-value fluorinated aromatic amine building block, distinguished by its unique combination of fluorine and trifluoromethyl substituents. This compound is critical for introducing specific physicochemical properties into target molecules, such as enhanced metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine motifs contribute to improved pesticidal activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), enhancing charge transport and stability.
• Polymer Modification: Employed to introduce fluorine-containing functional groups into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to construct complex nitrogen-containing aromatic systems.
• Protease Inhibitor Research: Acts as a precursor in the development of enzyme inhibitors, leveraging the benzylamine moiety for targeted binding.

Basic Information

Product Name	2-Fluoro-5-(trifluoromethyl)benzylamine
CAS No.	199296-61-2
Molecular Formula	C8H7F4N
Molecular Weight	193.14 g/mol
Synonyms	(2-Fluoro-5-(trifluoromethyl)phenyl)methanamine; 1-(Aminomethyl)-2-fluoro-5-(trifluoromethyl)benzene; α-Fluoro-α,α,α-trifluoro-m-toluidine (ambiguous, not preferred); 2-Fluoro-5-trifluoromethylbenzylamine; 2-Fluoro-alpha,alpha,α-trifluoro-m-toluamine; 2-Fluoro-5-(trifluoromethyl)benzenemethanamine; [2-Fluoro-5-(trifluoromethyl)phenyl]methylamine
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(trifluoromethyl)benzylamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our standard grades typically conform to research and commercial specifications, with custom purity levels available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This amine is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.