Description

Nsp-Sa-Nhs CAS NO 199293-83-9 is a specialized, high-purity chemical intermediate widely used in advanced organic synthesis and bioconjugation chemistry. Its primary value lies in its role as a highly reactive active ester, enabling efficient and selective coupling reactions under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors who require reliable building blocks for peptide synthesis, antibody-drug conjugate (ADC) development, and surface functionalization.

Application

• Peptide Synthesis: A key reagent for the efficient formation of amide bonds in solid-phase and solution-phase peptide synthesis.
• Antibody-Drug Conjugates (ADCs): Used as a linker component to covalently attach cytotoxic payloads to monoclonal antibodies for targeted cancer therapies.
• Protein Labeling & Bioconjugation: Facilitates the site-specific labeling of proteins, antibodies, and other biomolecules with fluorescent dyes, drugs, or other functional groups.
• Surface Modification: Employed to functionalize nanoparticles, microarrays, and other solid supports with amine-reactive groups for biosensor and diagnostic device fabrication.
• Cross-linking Agent: Serves as a homobifunctional cross-linker for conjugating amine-containing molecules in material science and polymer chemistry.
• Intermediate for Fine Chemicals: Acts as a crucial building block in the multi-step synthesis of complex pharmaceutical agents and other high-value fine chemicals.

Basic Information

Product Name	Nsp-Sa-Nhs
CAS No.	199293-83-9
Molecular Formula	C16H16N2O8
Molecular Weight	364.31 g/mol
Synonyms	N-Succinimidyl 4-(4-Nitrophenoxy)butyrate; 4-Nitrophenyl 4-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-4-oxobutanoate; 4-(4-Nitrophenoxy)butyric Acid N-Hydroxysuccinimide Ester; N-Hydroxysuccinimide Ester of 4-(4-Nitrophenoxy)butyric Acid; NHS Ester of 4-(p-Nitrophenoxy)butyric Acid; Nsp-Sa-NHS; 199293-83-9; PNPO-Bu-OSu
EINECS	Contact for details

Quality Control

Our Nsp-Sa-Nhs is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems support development from research to commercial scale, ensuring reliable supply and regulatory compliance for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.