Description

(3Rs)-n-Methyl-3-Phenyl-3-[2-(Trifluoromethyl)-Phenoxy]Propan-1-Amine Hydrochloride (2-Trifluoromethylisomer Of Fluoxetine Hydro-Chloride) is a high-purity, structurally specific isomer of a well-known pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly for creating novel therapeutic agents with targeted activity. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in neuropharmacology and selective serotonin reuptake inhibitor (SSRI) analog synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel antidepressant and neuropharmacological agent analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of trifluoromethyl positional isomerism on biological activity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry Development: Employed in route scouting and optimization for the production of specialized active pharmaceutical ingredients (APIs).
• Biochemical Research: Tool compound for investigating serotonin transporter (SERT) binding and function in vitro.
• Custom Synthesis: Starting material for the preparation of deuterated, radiolabeled, or other modified derivatives for advanced research applications.

Basic Information

Product Name	(3Rs)-n-Methyl-3-Phenyl-3-[2-(Trifluoromethyl)-Phenoxy]Propan-1-Amine Hydrochloride (2-Trifluoromethylisomer Of Fluoxetine Hydro-Chloride)
CAS No.	199188-97-1
Molecular Formula	C17H17F3NO•HCl
Molecular Weight	347.78 g/mol
Synonyms	2-Trifluoromethylfluoxetine Hydrochloride; (R,S)-N-Methyl-3-phenyl-3-[2-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride; Fluoxetine 2-CF3 isomer HCl; (RS)-Fluoxetine 2-trifluoromethyl isomer hydrochloride; (±)-N-Methyl-γ-[2-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride; 3-Phenyl-3-[2-(trifluoromethyl)phenoxy]-N-methylpropylamine hydrochloride (isomer); Benzenepropanamine, N-methyl-γ-[2-(trifluoromethyl)phenoxy]-, hydrochloride, (±)-
EINECS	Contact for details

Quality Control

Our (3Rs)-n-Methyl-3-Phenyl-3-[2-(Trifluoromethyl)-Phenoxy]Propan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm isomeric composition, and identity confirmation via IR and NMR. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, ensuring full traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (RS mixture specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.