Description

Z-Gln[Trt]-Ol CAS NO 199006-31-0 is a protected glutamine derivative, specifically an N-benzyloxycarbonyl (Z) protected glutamine with a trityl (Trt) group on the side chain amide and an alcohol (Ol) terminus. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of glutamine while preventing unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential assembly of peptide chains on resin.
• Pharmaceutical Intermediate: Used in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Serves as a precursor for introducing glutamine residues into proteins or other molecules for modification studies.
• Chemical Biology Research: Employed in the synthesis of peptide probes, inhibitors, and tools for studying biological processes.
• Custom Peptide Manufacturing: A vital raw material for CROs and CDMOs producing bespoke peptides for clients.
• GPCR Ligand Development: Used in synthesizing peptide ligands for G-protein-coupled receptor research and drug discovery.

Basic Information

Product Name	Z-Gln[Trt]-Ol
CAS No.	199006-31-0
Molecular Formula	C32H32N2O4
Molecular Weight	508.61 g/mol
Synonyms	Nα-Z-Nγ-trityl-L-glutamine; Z-Gln(Trt)-OH; N-Cbz-N'-trityl-L-glutamine; Nα-Carbobenzoxy-Nγ-trityl-L-glutamine; (2S)-5-oxo-2-[[(phenylmethoxy)carbonyl]amino]-5-(tritylamino)pentanoic acid; Z-L-Glutamine(Trt)-OH; Fmoc-Gln(Trt)-OH precursor; Protected L-glutamine derivative
EINECS	Contact for details

Quality Control

Our Z-Gln[Trt]-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.