Description

4-Iodobenzoyl Cyanide is a versatile and high-value aromatic building block characterized by its reactive cyanide and iodo functional groups. This compound is essential for facilitating advanced cross-coupling reactions and serving as a key precursor in the synthesis of complex heterocyclic structures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, particularly those requiring iodinated aromatic cores for further functionalization.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, leveraging its reactivity to create novel bioactive compounds.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form biaryl structures.
• Heterocyclic Chemistry: The cyanide group is utilized in the construction of various nitrogen-containing heterocycles, such as pyridines, pyrimidines, and triazines.
• Chemical Biology & Proteomics: Can be used to develop molecular probes, tags, and inhibitors for studying biological systems and protein functions.

Basic Information

Product Name	4-Iodobenzoyl Cyanide
CAS No.	198978-33-5
Molecular Formula	C8H4INO
Molecular Weight	272.03 g/mol
Synonyms	p-Iodobenzoyl Cyanide; 4-Iodobenzonitrile, α-oxo-; (4-Iodophenyl)(oxo)acetonitrile; α-Oxo-4-iodobenzeneacetonitrile; 4-Cyanoformyl iodobenzene; 4-Iodobenzoyl nitrile; 4-Iodophenylglyoxylonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Iodobenzoyl Cyanide is manufactured and tested under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC), identity confirmation (by IR and NMR), and levels of specific impurities. Our quality systems are designed to support cGMP and ISO standards for pharmaceutical and industrial research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.