Description

Bexarotene Acyl-β-D-Glucuronide is a key metabolite and analytical reference standard of the synthetic retinoid bexarotene. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism and pharmacokinetics (DMPK). It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the development and quality control of retinoid-based therapies.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of bexarotene and its metabolites in biological matrices.
• Drug Metabolism Studies: Critical for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic pathway of bexarotene.
• Bioanalytical Method Development: Used as a standard for developing and validating sensitive HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring (TDM) and pharmacokinetic profiling.
• Impurity Profiling: Employed in the identification and quantification of glucuronidated metabolites as potential impurities in active pharmaceutical ingredient (API) batches of bexarotene.
• Toxicology Research: Facilitates research into the safety and toxicity profile of bexarotene metabolites.
• Clinical Research: Supports clinical trials for cutaneous T-cell lymphoma (CTCL) and other oncological indications where bexarotene is investigated.

Basic Information

Product Name	Bexarotene Acyl-β-D-Glucuronide
CAS No.	198700-33-3
Molecular Formula	C34H40O9
Molecular Weight	592.68 g/mol
Synonyms	Bexarotene Glucuronide; Bexarotene Acyl Glucuronide; 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid β-D-Glucopyranosiduronic acid; LG-100754 Glucuronide; Targretin Glucuronide; (2S,3S,4S,5R,6S)-6-[[4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl]benzoyl]oxy]-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Bexarotene Acyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). Certificates of Analysis (COA) detailing batch-specific results are available upon request to ensure full traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.