Description

Fmoc-3-Chloro-L-Phenylalanine CAS NO 198560-44-0 is a protected, non-natural amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the unique 3-chloro-L-phenylalanine residue into peptide sequences, enabling the development of novel peptides with modified properties for research and therapeutic applications. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories focused on peptide-based drug discovery, chemical biology, and proteomics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated synthesis of custom peptides containing chlorinated phenylalanine analogs.
• Pharmaceutical Research: Used in the development of peptide therapeutics, hormone analogs, and enzyme inhibitors where halogenation can enhance binding affinity, metabolic stability, or alter physicochemical properties.
• Chemical Biology Probes: Incorporation into peptides to create photoaffinity labels, activity-based probes, or bioconjugation handles for studying protein-protein interactions.
• Material Science: Serves as a precursor for synthesizing specialized monomers used in peptide-polymer conjugates or biomimetic materials.
• Process Development: Employed in the scale-up and GMP manufacturing of active pharmaceutical ingredients (APIs) for clinical-stage peptide drugs.

Basic Information

Product Name	Fmoc-3-Chloro-L-Phenylalanine
CAS No.	198560-44-0
Molecular Formula	C24H20ClNO4
Molecular Weight	421.87 g/mol
Synonyms	Fmoc-3-chloro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-chloro-L-phenylalanine; Fmoc-3-Cl-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(3-chlorophenyl)propanoic acid; N-Fmoc-3-chloro-L-phenylalanine; Fmoc-L-3-chlorophenylalanine; Fmoc-3-chloro-L-Phe; 3-Chloro-L-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-3-Chloro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.