Description

Fmoc-L-2-Chlorophe CAS NO 198560-41-7 is a protected amino acid derivative, specifically an Fmoc-protected chlorophenylalanine analog, essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for ensuring the fidelity and efficiency of complex peptide chain assembly. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to study structure-activity relationships (SAR), particularly where the chlorophenyl moiety influences receptor binding or metabolic stability.
• Bioconjugation & Probe Development: Serving as a precursor for synthesizing fluorescently labeled or affinity-tagged peptides used in cellular imaging and proteomics.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Fundamental studies in biochemistry, medicinal chemistry, and chemical biology involving peptide design and function.
• Fine Chemical Intermediate: Further chemical modification for the production of more complex, non-natural amino acid derivatives or specialized chiral building blocks.

Basic Information

Item	Detail
Product Name	Fmoc-L-2-Chlorophe CAS NO 198560-41-7
CAS No.	198560-41-7
Molecular Formula	C24H20ClNO4
Molecular Weight	421.87 g/mol
Synonyms	Fmoc-2-chloro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-chloro-L-phenylalanine; Fmoc-L-2-chlorophenylalanine; Fmoc-2-Cl-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2-chlorophenyl)propanoic acid; N-Fmoc-2-chloro-L-phenylalanine; Fmoc-2-chloro-L-Phe; Fmoc-L-(2-chlorophenyl)alanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-Chlorophe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for peptide synthesis. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with every shipment to guarantee reproducible performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); desiccate for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.