Description

Fmoc-D-3-Fluorophe CAS NO 198545-72-1 is a high-purity, fluorinated amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides, enabling the precise introduction of fluorinated aromatic side chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools where structural modification is key to enhancing biological activity and stability.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research & Development: For incorporating fluorinated phenylalanine analogs into peptide drug candidates to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorophore-labeled or bioactive peptide probes for imaging and diagnostic applications.
• Chemical Biology Studies: Used to investigate protein structure-function relationships by site-specifically introducing fluorine atoms via peptide incorporation.
• Process Development & Scale-Up: Suitable for use in cGMP manufacturing of peptide active pharmaceutical ingredients (APIs) for clinical trials and commercial supply.

Basic Information

Product Name	Fmoc-D-3-Fluorophe CAS NO 198545-72-1
CAS No.	198545-72-1
Molecular Formula	C24H20FNO4
Molecular Weight	405.42 g/mol
Synonyms	Fmoc-3-fluoro-D-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-fluoro-D-phenylalanine; Fmoc-D-Phe(3-F)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid; N-α-Fmoc-3-fluoro-D-phenylalanine; Fmoc-3-F-D-Phe-OH; Fmoc-D-3-Fluorophenylalanine; BOC Sciences Brand Name: BBL-BB-015-0030
EINECS	Contact for details

Quality Control

Our Fmoc-D-3-Fluorophe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the exacting standards required for peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.