Description

Fmoc-D-3,4-Difluorophe CAS NO 198545-59-4 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block in the development of complex peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics, and the synthesis of therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides containing D-3,4-difluorophenylalanine residues.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the research and development of novel peptide drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to incorporate fluorinated aromatic side chains into peptide backbones, enhancing metabolic stability and binding affinity in drug candidates.
• Biochemical Research: Employed in academic and industrial laboratories for studying protein-protein interactions, enzyme specificity, and structure-activity relationships (SAR).
• Labeled Peptide Synthesis: A precursor for creating peptides with specific fluorinated tags for use in imaging and diagnostic applications.

Basic Information

Product Name	Fmoc-D-3,4-Difluorophe
CAS No.	198545-59-4
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-D-3,4-Difluorophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-difluoro-D-phenylalanine; Fmoc-3,4-Difluoro-D-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,4-difluorophenyl)propanoic acid; N-Fmoc-3,4-difluoro-D-phenylalanine; Fmoc-D-F2Phe-OH; Fmoc-D-3,4-F2Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-3,4-Difluorophe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and chiral analysis to confirm enantiomeric excess. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.