Description

Dapsone Hydroxylamine Deuterated is a stable isotope-labeled analog of dapsone hydroxylamine, a key metabolite of the antibacterial and anti-inflammatory drug dapsone. This deuterated compound is an essential reference standard and internal standard for advanced analytical applications, providing critical support for precise quantification and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) research, bioanalytical method development, and clinical trial support.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of dapsone and its metabolites in biological matrices using LC-MS/MS.
• For use in drug metabolism and pharmacokinetic (DMPK) studies to investigate the metabolic pathways and clearance mechanisms of dapsone.
• In the development and validation of bioanalytical methods for clinical and preclinical trials involving dapsone-based therapies.
• As a critical reference material in forensic and anti-doping analysis to confirm the presence of dapsone or its metabolites.
• Supporting research into mechanistic toxicology, particularly studies focused on dapsone-induced methemoglobinemia and hydroxylamine-mediated toxicity.
• For use in environmental fate studies tracking the degradation and transformation of pharmaceutical compounds.

Basic Information

Product Name	Dapsone Hydroxylamine Deuterated
CAS No.	198486-78-1
Molecular Formula	C12H10D2N2O2S
Molecular Weight	250.31 g/mol
Synonyms	4,4'-Sulfonylbis[deuterioaniline] N-Hydroxide; Dapsone-d2 Hydroxylamine; Dapsone Hydroxylamine-d2; 4-Amino-4'-aminosulfonyl-d2-diphenylamine N-Oxide; DDS-d2 Hydroxylamine; Dapsone N-Hydroxy-d2-amine; Deuterated Dapsone Hydroxylamine; [2H2]-Dapsone Hydroxylamine
EINECS	Contact for details

Quality Control

Every batch of Dapsone Hydroxylamine Deuterated is manufactured and tested to meet the stringent requirements for high-purity reference standards. Our quality assurance protocol includes comprehensive analytical characterization to confirm chemical identity, isotopic purity (deuterium enrichment), and chemical purity. Certificates of Analysis (COA) are provided, detailing results from NMR (1H, 13C), mass spectrometry, and HPLC analysis. We adhere to relevant quality management guidelines to ensure consistency and reliability for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.