Description

L-Phenylalanine, 4-[[[(2-Chlorophenyl)Methoxy]Carbonyl]Amino]-n-[(1,1-Dimethylethoxy)Carbonyl]- is a sophisticated, non-natural amino acid derivative designed for advanced chemical synthesis. This compound is a critical protected building block for researchers and manufacturers requiring high-purity, structurally defined intermediates. It is primarily utilized in the development of novel pharmaceuticals, peptide-based therapeutics, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for CNS and metabolic disorder targets.
• Peptide Synthesis: Serves as a Boc-protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS), enabling the construction of complex peptide sequences.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new drug candidates.
• Bioconjugation & Probe Development: Acts as a functionalized handle for creating labeled peptides or protein conjugates used in diagnostic and biochemical research.
• Chemical Biology: Employed in the synthesis of enzyme inhibitors, receptor ligands, and other bioactive tools for probing biological pathways.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and custom organic molecules for industrial and academic clients.

Basic Information

Product Name	L-Phenylalanine, 4-[[[(2-Chlorophenyl)Methoxy]Carbonyl]Amino]-n-[(1,1-Dimethylethoxy)Carbonyl]-
CAS No.	198475-65-9
Molecular Formula	C22H25ClN2O6
Molecular Weight	448.90 g/mol
Synonyms	Boc-Phe(2-Cl-Z)-OH; N-[(tert-Butoxy)carbonyl]-O-[(2-chlorobenzyloxy)carbonyl]-L-tyrosine; N-Boc-O-(2-chlorobenzyloxycarbonyl)-L-tyrosine; (2S)-3-(4-[[[(2-Chlorophenyl)methoxy]carbonyl]amino]phenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; Boc-L-Tyr(2-Cl-Z)-OH; Boc-Tyr(2-Cl-Z)-OH; Fmoc-Tyr(2-Cl-Z)-OH precursor; N-Boc-O-(2-chlorobenzyloxycarbonyl)tyrosine
EINECS	Contact for details

Quality Control

Our L-Phenylalanine derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. All products undergo rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Specification available upon request
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.