Description

9-Hydroxy Topiramate is a key pharmaceutical intermediate and metabolite of the anticonvulsant drug Topiramate. This compound matters for its critical role in drug metabolism studies, analytical reference standard preparation, and the development of novel therapeutic agents. It is primarily needed by research institutions, pharmaceutical manufacturers, and analytical laboratories focused on neurology and metabolic pathway research. The product is identified by the CAS registry number 198215-62-2.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis and research of Topiramate and its derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods (LC-MS, HPLC) for quantifying Topiramate and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and clearance of Topiramate.
• Impurity Profiling: Employed as a certified reference material to identify and quantify related substances in Topiramate Active Pharmaceutical Ingredient (API).
• Research & Development: Utilized in academic and industrial R&D for exploring new neurological therapies and understanding drug mechanisms of action.
• Quality Control: Acts as a system suitability standard in pharmaceutical quality control laboratories to ensure assay accuracy and specificity.

Basic Information

Product Name	9-Hydroxy Topiramate
CAS No.	198215-62-2
Molecular Formula	C12H21NO8S
Molecular Weight	339.36 g/mol
Synonyms	9-Hydroxytopiramate; 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate (9-hydroxy derivative); Topiramate Metabolite; 9-OH-Topiramate; 9-Hydroxy-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate; 198215-62-2; 9-Hydroxy-4,5:2,3-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
EINECS	Contact for details

Quality Control

Our 9-Hydroxy Topiramate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.