Description

2-(3,5-Difluorophenyl)-1,3-Dioxolane is a high-purity fluorinated organic intermediate featuring a dioxolane-protected aldehyde or ketone functionality. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the controlled introduction of a difluorophenyl moiety. It is primarily sought by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging the stability and bioactivity of the difluorophenyl group.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials for enhanced performance characteristics.
• Custom Chemical Synthesis: Provides a protected carbonyl equivalent for multi-step synthetic routes in contract research and manufacturing (CRAM) organizations.

Basic Information

Product Name	2-(3,5-Difluorophenyl)-1,3-Dioxolane
CAS No.	197785-23-2
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	1,3-Dioxolane, 2-(3,5-difluorophenyl)-; 3,5-Difluorobenzaldehyde ethylene acetal; (3,5-Difluorophenyl)-1,3-dioxolane; 2-(3,5-Difluorophenyl)-[1,3]dioxolane; Benzaldehyde, 3,5-difluoro-, cyclic ethylene acetal; 3,5-Difluorobenzaldehyde cyclic ethylene acetal
EINECS	Contact for details

Quality Control

Every batch of 2-(3,5-Difluorophenyl)-1,3-Dioxolane is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/GC), identity (by IR, NMR), and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.