Description

n-Me-Asp(Otbu)-Oh CAS NO 197632-85-2 is a protected aspartic acid derivative, specifically an N-methyl aspartic acid β-tert-butyl ester. This compound serves as a crucial building block (synthon) in advanced organic synthesis, particularly for the construction of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams requiring high-purity, specialized amino acid derivatives.

Application

• Pharmaceutical Intermediates: Key building block in the synthesis of novel peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to create modified peptide structures with enhanced metabolic stability or bioavailability for drug discovery.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected, N-methylated amino acid derivative to introduce specific conformational constraints into peptide chains.
• Bioconjugation & Labeling: Serves as a precursor for creating specialized linkers or tags in bioconjugation chemistry.
• Academic & Industrial R&D: Fundamental reagent for research in medicinal chemistry, chemical biology, and organic synthesis methodologies.

Basic Information

Product Name	n-Me-Asp(Otbu)-Oh
CAS No.	197632-85-2
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)methylamino]butanedioic acid 1-tert-butyl ester; N-Methyl-L-aspartic acid 4-tert-butyl ester; (S)-2-(N-Methylamino)succinic acid 4-tert-butyl ester; Boc-N-Me-Asp(OtBu)-OH; Fmoc-N-Me-Asp(OtBu)-OH (protected form); N-Methylaspartic acid β-tert-butyl ester; N-Me-Asp(OtBu)-OH; N-Methyl-L-aspartic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Me-Asp(Otbu)-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.