Description

Cyclononyne, 3,3-Diethoxy- (9Ci) is a specialized strained alkyne derivative, a key building block in advanced organic synthesis. This compound matters for its unique reactivity profile, enabling efficient bioorthogonal chemistry and click chemistry reactions under mild conditions. It is primarily needed by researchers and process chemists in the pharmaceutical, biotechnology, and materials science industries for applications such as bioconjugation, polymer functionalization, and the development of novel chemical probes. Its stability and selectivity make it a valuable reagent for constructing complex molecular architectures.

Application

• Bioorthogonal Labeling and Imaging: Used as a strained alkyne reagent for copper-free click chemistry with azides to label biomolecules (proteins, nucleic acids) in live cells for imaging and diagnostic applications.
• Bioconjugation and ADC Development: Serves as a linker or functional handle for site-specific conjugation of drugs, toxins, or fluorophores to antibodies in the development of Antibody-Drug Conjugates (ADCs) and other therapeutic biologics.
• Polymer and Materials Science: Employed to functionalize polymer backbones or surfaces via click reactions, enabling the creation of smart materials, hydrogels, and functional coatings with tailored properties.
• Chemical Probe Synthesis: A critical intermediate in synthesizing activity-based probes and affinity tags for proteomics research and target identification in drug discovery.
• Peptide and Protein Modification: Facilitates the post-translational, site-specific modification of peptides and proteins for studying protein function or improving pharmacokinetic properties.
• Radiochemistry: Can be utilized for the radiolabeling of biomolecules with isotopes like Fluorine-18 for Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	Cyclononyne, 3,3-Diethoxy- (9Ci)
CAS No.	197312-32-6
Molecular Formula	C₁₃H₂₂O₂
Molecular Weight	210.31 g/mol
Synonyms	3,3-Diethoxycyclononyne; BCN-OEt; BCN Ethoxy; Dibenzocyclooctyne Ethoxy Derivative; BCN Ester (common misnomer); 3,3-Bis(ethoxy)cyclononyne; Cyclononyne, 3,3-diethoxy-; BCN-based reagent
EINECS	Contact for details

Quality Control

Our Cyclononyne, 3,3-Diethoxy- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to prolonged exposure to light and moisture. Keep container tightly sealed under an inert atmosphere for long-term storage to maintain optimal stability and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.