Description

1S,5S,6S-(-)-1,6-Bis(Diphenylphosphinoxy)Spiro[4.4]Nonane CAS NO 197252-01-0 is a chiral, bidentate phosphinite ligand featuring a unique spirocyclic backbone. This compound matters for its exceptional ability to induce high enantioselectivity in transition metal-catalyzed asymmetric reactions, a critical factor in producing optically pure intermediates. It is primarily needed by research chemists and process development scientists in the pharmaceutical and fine chemical industries for applications such as asymmetric hydrogenation and cross-coupling.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for the synthesis of enantiomerically pure pharmaceutical intermediates.
• Catalyst component for enantioselective C-C bond formation (e.g., cross-coupling, allylic alkylation).
• Use in academic and industrial R&D for developing novel catalytic processes.
• Key reagent for the synthesis of chiral natural products and complex organic molecules.
• Potential application in material science for creating chiral surfaces or polymers.

Basic Information

Product Name	1S,5S,6S-(-)-1,6-Bis(Diphenylphosphinoxy)Spiro[4.4]Nonane
CAS No.	197252-01-0
Molecular Formula	C33H32O2P2
Molecular Weight	522.55 g/mol
Synonyms	(-)-1,6-Bis(diphenylphosphinoxy)spiro[4.4]nonane; (1S,5S,6S)-1,6-Bis(diphenylphosphanyloxy)spiro[4.4]nonane; Spiro[4.4]nonane-1,6-diyl bis(diphenylphosphinite); (S,S)-SKP Ligand; Chiral Spiro Phosphinite Ligand; 1,6-Bis(diphenylphosphinoxy)spiro[4.4]nonane; (1S,5S,6S)-1,6-Bis(diphenylphosphoryloxy)spiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.