Description

Adenosine-15N N1-Oxide is a stable isotope-labeled derivative of adenosine, specifically enriched with nitrogen-15 at the N1-oxide position. This compound is essential for advanced research in metabolic tracing and NMR spectroscopy, providing critical insights into nucleoside pathways and oxidative stress mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers engaged in isotope dilution mass spectrometry and the study of purine metabolism.

Application

• Metabolic Pathway Tracing: Used as an internal standard in LC-MS/MS and GC-MS for the quantitative analysis of adenosine and its metabolites in biological samples.
• NMR Spectroscopy Studies: Serves as a crucial probe for investigating nucleoside structure, dynamics, and interactions due to the 15N label.
• Pharmaceutical Research & Development: Employed in the development and validation of analytical methods for drug candidates targeting purinergic receptors.
• Biochemical Research: Facilitates studies on adenosine receptor signaling, oxidative damage to nucleic acids, and enzyme kinetics.
• Diagnostic Assay Development: Acts as a reference material in calibrating assays for clinical research related to cardiovascular and neurological disorders.

Basic Information

Product Name	Adenosine-15N N1-Oxide
CAS No.	197227-85-3
Molecular Formula	C10H12N5O5 * (15N at N1-Oxide)
Molecular Weight	Contact for details
Synonyms	9-β-D-Ribofuranosyladenine-15N N1-Oxide; Adenosine-15N 1-Oxide; 15N-Labeled Adenosine N1-Oxide; 15N-Adenosine 1-Oxide; Isotopically Labeled Adenosine Derivative; [15N]Adenosine N1-Oxide; Purine Nucleoside-15N Oxide
EINECS	Contact for details

Quality Control

Our Adenosine-15N N1-Oxide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and isotopic enrichment verification via mass spectrometry, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data and spectroscopic confirmation are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % 15N
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.