Description

n-Acetyl-3-Chloro-D-Phenylalanine is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This chiral building block is engineered to provide researchers with a specific, modified structural motif for probing biological systems and creating novel therapeutic agents. It is primarily utilized by pharmaceutical companies and research institutions engaged in peptide synthesis, medicinal chemistry, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological disorders.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate a chlorinated, acetyl-protected phenylalanine residue, modifying peptide stability and bioactivity.
• Medicinal Chemistry & SAR Studies: Serves as a critical building block for structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Enzyme Inhibitor Development: Acts as a precursor or core structure in designing inhibitors for specific enzymes, such as proteases or transferases.
• Biochemical Research: Employed as a substrate or analog in biochemical assays to study enzyme mechanisms and metabolic pathways.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	n-Acetyl-3-Chloro-D-Phenylalanine
CAS No.	197087-50-6
Molecular Formula	C11H12ClNO3
Molecular Weight	241.67 g/mol
Synonyms	N-Acetyl-3-chloro-D-phenylalanine; (R)-2-Acetamido-3-(3-chlorophenyl)propanoic acid; Ac-3-Cl-D-Phe-OH; 3-Chloro-N-acetyl-D-phenylalanine; D-3-Chloro-N-acetylphenylalanine; N-Acetyl-3-chloro-(R)-phenylalanine; N-Acetyl-O-chloro-D-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-3-Chloro-D-Phenylalanine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as chiral purity, chemical purity (HPLC), and residual solvents. Our quality management system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.