Description

(S)-5-Hydroxy Omeprazole CAS NO 196489-27-7 is a high-purity, chiral active pharmaceutical intermediate (API) and a key metabolite of the proton pump inhibitor Omeprazole. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced gastroesophageal research and chiral chemistry.

Application

• Pharmaceutical Intermediate: Critical chiral building block for the synthesis of advanced proton pump inhibitors and related therapeutic compounds.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies for quantifying Omeprazole and its metabolites in biological matrices.
• Pharmacokinetic & Metabolic Research: Essential for investigating the metabolic pathways, bioavailability, and elimination profiles of Omeprazole.
• Chiral Synthesis: Serves as a starting material or intermediate in the asymmetric synthesis of enantiomerically pure drug molecules.
• Quality Control & Impurity Profiling: Employed in pharmaceutical QC laboratories to identify and quantify related substances and degradation products.
• Academic & Clinical Research: Supports fundamental research in gastroenterology, enzymology, and drug-receptor interaction studies.

Basic Information

Product Name	(S)-5-Hydroxy Omeprazole
CAS No.	196489-27-7
Molecular Formula	C17H19N3O4S
Molecular Weight	361.42 g/mol
Synonyms	(S)-Omeprazole 5-Hydroxy Metabolite; (S)-5-Hydroxyomeprazole; 5-Hydroxy Omeprazole (S-enantiomer); (S)-5-Hydroxy-6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; (S)-H 168/68 5-OH; (S)-Form of Omeprazole Sulfone; (S)-5-OH Omeprazole; ES Omeprazole Metabolite
EINECS	Contact for details

Quality Control

Our (S)-5-Hydroxy Omeprazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with stringent specifications suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.