Description

(Cys(Et)2,7)-α-Cgrp (Human) CAS NO 196413-73-7 is a synthetic, chemically modified analog of the human α-Calcitonin Gene-Related Peptide (α-CGRP). This engineered peptide is of significant value for advanced research and development in neuroscience and pharmacology, specifically targeting the CGRP receptor system. It is primarily required by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on migraine therapeutics, neurovascular research, and peptide-based drug discovery.

Application

• Neuroscience Research: Used as a potent, selective tool compound for studying the structure-activity relationship (SAR) of the α-CGRP receptor and its signaling pathways.
• Drug Discovery & Development: Serves as a critical reference standard and lead compound in the development of novel CGRP receptor antagonists and modulators for migraine and other neurovascular disorders.
• Biochemical Assays: Employed in competitive binding assays (e.g., ELISA, RIA) and functional cellular assays to evaluate the potency and efficacy of new therapeutic candidates.
• Pharmacological Studies: Facilitates in vitro and ex vivo studies to understand vasodilation, nociception, and the role of CGRP in inflammatory processes.
• Peptide Chemistry & Conjugation: Acts as a model substrate for developing novel peptide modification, stabilization, and conjugation techniques due to its specific disulfide bridge and ethylated cysteine residues.

Basic Information

Product Name	(Cys(Et)2,7)-α-Cgrp (Human)
CAS No.	196413-73-7
Molecular Formula	C148H244N44O42S2
Molecular Weight	~3265.9 g/mol
Synonyms	α-CGRP (Human) [Cys(Et)2,7] analog; [Cys(Et)2,7]-h-α-CGRP; Human α-Calcitonin Gene-Related Peptide analog with ethylated cysteines at positions 2 and 7; CGRP-I (8-37) derivative; Modified CGRP antagonist analog; h-α-CGRP ethyl-cysteine analog; CGRP receptor ligand; (Cys(Et)2,7)-h-α-CGRP
EINECS	Contact for details

Quality Control

Our (Cys(Et)2,7)-α-Cgrp (Human) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.