Description

Exendin (5-39) is a synthetic peptide fragment of exendin-4, a glucagon-like peptide-1 (GLP-1) receptor antagonist. This compound is a critical research tool for studying GLP-1 receptor signaling pathways and metabolic regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on diabetes, obesity, and metabolic disease research.

Application

• Pharmacological Research: Used as a selective GLP-1 receptor antagonist to investigate the physiological roles of GLP-1 in glucose homeostasis and insulin secretion.
• Metabolic Disease Studies: Essential for in vitro and in vivo models to understand the mechanisms of action of GLP-1 agonists and to explore new therapeutic targets for diabetes and obesity.
• Biochemical Assay Development: Serves as a reference standard or control compound in competitive binding assays (e.g., receptor binding, ELISA) and functional cellular assays.
• Neuroscience Research: Investigates the role of GLP-1 receptors in the central nervous system, including effects on neuroprotection, appetite regulation, and cognitive function.
• Cardiovascular Research: Explores the cardioprotective effects and signaling pathways mediated by GLP-1 receptors.
• Preclinical Tool Compound: Used in animal studies to validate the specificity of GLP-1-mediated effects and to block endogenous GLP-1 activity.

Basic Information

Product Name	Exendin (5-39)
CAS No.	196109-27-0
Molecular Formula	C₁₆₄H₂₅₂N₄₄O₅₀S
Molecular Weight	3770.1 g/mol
Synonyms	Exendin 5-39; Exendin (9-39); [Des-His¹, Glu²]Exendin-4 (5-39); Exendin-4 (5-39) amide; GLP-1 Receptor Antagonist, Exendin-based; H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂; Exendin-4 fragment 5-39
EINECS	Contact for details

Quality Control

Our Exendin (5-39) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. For specific purity grades or custom QC requirements, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere or with desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Confirmed by in vitro receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.